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 Nephrogenic Systemic Fibrosis (NSF) or Nephrogenic Fibrosing Dermopathy (NFD) symptoms initially affect the skin. Most NSF/NFD patients with describe a swelling and tightening of the skin, and these effects and typically limited to the extremities but can sometimes involving the trunk.
Symptoms of Nephrogenic Systemic Fibrosis or Nephrogenic Fibrosing Dermopathy can appear anywhere from one day to 2 years after a patient has been exposed to a Gadolinium. Most patients eventually may be unable to walk, or fully extend the joints of their arms, hands, legs, and feet. Most people diagnosed with NSF/NSD are first found to have high blood pressure. In extreme cases patientness is also common.
A Skin Biopsy is used to Diagnose Nephrogenic Systemic Fibrosis (NSF) or Nephrogenic Fibrosing Dermopathy (NFD). Other Warning Signs and Symptoms Include:
• Yellow spots on the whites of the eyes
• Stiffness in joints and trouble moving or straightening the arms, hands, legs, or feet
• Tightening and swelling of the skin
• Hardening and thickening of the skin around the joints, restricting movement
• Extremely hard or rough skin has the texture of an orange peel
• Red or dark patches on the skin
• Burning, itching, and/or sharp pains in affected areas
• Symmetrical skin lesions
• Muscle weakness and hardening of soft tissues.
• Deep bone pain in the hips and ribs
• Calcification of soft tissues
Nephrogenic Systemic Fibrosis (NSF) or Nephrogenic Fibrosing Dermopathy (NFD) can progress to the point of causing severe stiffness in joints, and it can lead to death. The progression of the disease can be slow, and it can take several years for all of the symptoms associated with NSF/NSD to appear. However, some patients have a form of NSF/NSD that progresses so quickly that they often die of complications brought on by the disease.
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